Antidepressant-like effects of extracts isolated from rhizomes of Cyperus rotundus L

Objective To investigate the antidepressant-like effects of extracts isolated from rhizomes of Cyperus rotundus L.(CR) for the first time. Methods Three models,the mouse forced swim test(FST),tail suspension test(TST) and open field test(OFT),were used to observe antidepressant-like effects of the 95% ethanol extract(XF-E) and the water extract(XF-W) isolated from CR. Results Firstly,in bioactive extract screening,compared with the model group(CMC-Na),XF-E(2 g/kg) significantly reduced the immobility time(IT) during FST and TST,while XF-W(2 g/kg) did not.Meanwhile,there was no significant difference among groups in crossed squares during OFT.Secondly,in dose-effect relationship assay,compared with the model group(CMC-Na),XF-E(1,2 g/kg) significantly reduced IT during FST and TST. Conclusion The present study indicates that XF-E can be bioactive extract of CR in antidepressant-like effect and appears in dose-dependent manners,for the first time.