Pharmacokinetics of gastrodigenin in rat plasma and CSF after intranasal and intravenous administration

Objective: To investigate the pharmacokinetics of gastrodigenin(p-hydroxybenzyl alcohol,HBA) in rat plasma and cerebrospinal fluid(CSF) after intravenous(i.v.) and intranasal(i.n.) administration.Methods: HBA was administered via i.v.at a dose of 50 or 10 mg·kg-1 and via i.n.at 10 mg·kg-1.Blood and CSF were collected at timed intervals for the measurement of HBA concentrations by high performance liquid chromatography.The calculations of pharmacokinetic parameters were performed by non-compartmental analysis using the software DAS 2.0.Results: HBA rapidly entered CSF after administration.AUCCSF was higher than AUCplasma.There was no significant difference in AUCCSF or AUCplasma between i.n.and i.v.administrations.Conclusion: HBA can be absorbed into the systemic circulation rapidly and completely after intranasal administration.Intranasal HBA may be a promising alternative to intravenous administration.No extra direct nose-CSF transport could be demonstrated.