Nitrofurantoin Susceptibility in Urinary Tract Infections (UTIs) in an Era of Drug Resistance

UTI are the most common bacterial infections that account for significant morbidity and health care cost world-wide. The most profound advance in the management of UTIs has been the introduction of antimicrobial agents. An old drug Nitrofurantoin has increased as a solution to the ever increasing menace of antimicrobial resistance. In this study, we studied the susceptibility pattern of Nitrofurantoin to the common uropathogens. Study was conducted from January 2015 to December 2015 in VIMS hospital Ballari. All the urine isolates are subjected to susceptibility for Nitrofurantoin and results were interrupted. Among 1372 urinary isolates, 86.7% of E.Coli, 89.9% of S.aureus, 92.3% of Enterobacter spp, 88.6% of Klebsiella spp, 90% of Enterococcus were susceptible to Nitrofurantoin. Overall Nitrofurantoin showed 89.3% of susceptibility and 10.7% of resistance in urinary isolates. In this study nitrofurantoin showed 89.3% of susceptibility to the most common urinary isolates. Nitrofurantoin should be considered as an acceptable treatment for uncomplicated UTIs and should be considered the first line treatment.