Synthesis, NMR and conformational studies of some 1,4- linked disaccharides

Synthesis of, and NMR and conformational studies on the methyl glycosides of some 1,4-linked disaccharides, containing rhamnose and fucose in the methyl glycoside residue, have been performed. The glycosylation shifts were correlated with inter-residue atomic distances found in the calculated minimum energy conformations. It is concluded that a typical set of glycosylation shifts are obtained for the disaccharides thus making it possible to use these in the analysis of complex carbohydrates.