化学
脱氢丙氨酸
酰化
丝氨酸
组合化学
色氨酸
对映体药物
氨基酸
衍生工具(金融)
立体化学
有机化学
酶
催化作用
生物化学
对映选择合成
经济
金融经济学
作者
Georg Blaser,John M. Sanderson,Andrei S. Batsanov,Judith A. K. Howard
标识
DOI:10.1016/j.tetlet.2008.02.120
摘要
This study reports a facile method for the synthesis of a variety of 5- and 6-substituted tryptophan derivatives that are difficult to prepare using alternative enzymatic approaches. Acylation of an activated amino acid, derived from serine in situ, is coupled with an enzymatic resolution step to furnish enantiopure analogues bearing a range of electron withdrawing and releasing substituents. Isolation of a dehydroalanine derivative as a by-product from some reactions provides some insights into the likely mechanism of the reaction.
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