5-羟色胺能
血清素
焦虑
抗抑郁药
神经递质
受体
神经科学
萧条(经济学)
5-羟色胺受体
动物研究
抗焦虑药
内科学
抑郁症动物模型
内分泌学
心理学
药理学
医学
精神科
宏观经济学
经济
作者
Elżbieta Żmudzka,Kinga Sałaciak,Jacek Sapa,Karolina Pytka
出处
期刊:Life Sciences
[Elsevier]
日期:2018-10-01
卷期号:210: 106-124
被引量:118
标识
DOI:10.1016/j.lfs.2018.08.050
摘要
Serotonin regulates many physiological processes including sleep, appetite, and mood. Thus, serotonergic system is an important target in the treatment of psychiatric disorders, such as major depression and anxiety. This natural neurotransmitter interacts with 7 families of its receptors (5-HT1-7), which cause a variety of pharmacological effects. Using genetically modified animals and selective or preferential agonists and antagonist, numerous studies demonstrated the involvement of almost all serotonin receptor subtypes in antidepressant- or anxiolytic-like effects. In this review, based on animal studies, we discuss the possible involvement of serotonin receptor subtypes in depression and anxiety.
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