This chapter provides information on the various abiotic and biotic factors impacting the colonization, development and establishment of Diaphorina citri through effects on its biology, ecology and management. These abiotic factors, such as temperature, humidity, light and rain, not only have direct impact on D. citri and the biotic drivers of its populations, but also play a very important role indirectly through effects on the host plants, which then affects both the pest and its natural enemies.