Therapeutic mechanism of Yupingfeng powder combined with montelukast in allergic rhinitis in children

Objective Through the test of serum interleukin-2 (IL-2), IL-4, and IgE in the peripheral blood of children with allergic rhinitis, to investigate the immune regulation mechanism of Yupingfeng powder combined with montelukast in allergic rhinitis. Methods 60 children in line with the diagnostic criteria of allergic rhinitis in inpatient or outpatient of our hospital were collected, and randomly divided into control group and treatment group, 28 healthy children without allergic rhinitis were selected as normal group. Normal group was not given any drug, control group was given alone montelukast (Singulair), treatment group was given Singulair and Yupingfeng powder. After 4 weeks of treatment, IL-2, IgE, IL-4 in the peripheral blood were measured. Results Before treatment, IL-2 level in the peripheral blood of children with allergic rhinitis was significantly lower than that of normal group (P 0.05); IL-4, IgE levels in the peripheral blood were significantly higher than those of normal group (P 0.05). After treatment, IL-2 level in the peripheral blood of children with allergic rhinitis was higher than that before treatment, there was statistically significant difference between normal group and control group (P 0.05); IL-4, IgE levels in the peripheral blood were lower than those before treatment, there were statistically significant differences between normal group and control group (P 0.05). Conclusion Yupingfeng powder combined with montelukast can effectively improve children' clinical symptoms, regulate the immune state of children in a certain extent, and boost the immune balance. Key words: Yupingfeng powder; Singulair; Allergic rhinitis; Therapeutic mechanism