适体
指数富集配体系统进化
计算生物学
生物医学
纳米技术
计算机科学
生物
生物化学
分子生物学
生物信息学
核糖核酸
材料科学
基因
作者
Long Li,Shujuan Xu,Yan He,Xiaowei Li,Hoda Safari Yazd,T. C. Huang,Cheng Cui,Jian‐Hui Jiang,Weihong Tan
标识
DOI:10.1002/anie.202003563
摘要
Abstract The advent of SELEX (systematic evolution of ligands by exponential enrichment) technology has shown the ability to evolve artificial ligands with affinity and specificity able to meet growing clinical demand for probes that can, for example, distinguish between the target leukemia cells and other cancer cells within the matrix of heterogeneity, which characterizes cancer cells. Though antibodies are the conventional and ideal choice as a molecular recognition tool for many applications, aptamers complement the use of antibodies due to many unique advantages, such as small size, low cost, and facile chemical modification. This Minireview will focus on the novel applications of aptamers and SELEX, as well as opportunities to develop molecular tools able to meet future clinical needs in biomedicine.
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