线性扫描伏安法
计时安培法
电极
循环伏安法
生物传感器
佩多:嘘
材料科学
聚(3,4-亚乙基二氧噻吩)
参比电极
线性范围
分析化学(期刊)
电化学
纳米技术
化学
检出限
色谱法
物理化学
作者
Jiansin Li,Xiang Bi,Sigitas Tamulevičius,Donāts Erts,Chiung-Fen Chang,Yesong Gu
标识
DOI:10.1016/j.jtice.2019.08.004
摘要
In this study, we have explored the potentiality of using GOx/AuNP/PEDOT(BSA)/Pt electrode as an implantable, long-lasting, and sensitive glucose biosensor. We have examined the performance of the electrode for glucose calibration with three electrochemical measurements, such as cyclic voltammetry, linear sweep voltammetry, as well as chronoamperometry, which all exhibited strong linear correlation between resulting signal and glucose concentration. In comparison, linear sweep voltammetry gave the best linear sensitivity, whose average was about 3.124 µA/mM/cm2 within a wide glucose concentration range from 0.416 to 50 mM. Meanwhile, the stability of the electrode was confirmed by a continuous glucose measurement in a 7-day period of time and the deviation was about 5%. The electrode was also biocompatibility according to the ISO109930-1 criterion. Furthermore, we have demonstrated that the oxidation of glucose on the GOx/AuNP/PEDOT(BSA)/Pt electrode was oxygen independent, therefore, it was not only easy to make but also feasible for continuous glucose monitoring systems.
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