埃法维伦兹
奈韦拉平
重组DNA
病毒学
生物
断点
遗传多样性
系统发育树
遗传学
拉伤
人类免疫缺陷病毒(HIV)
突变
基因
医学
染色体易位
抗逆转录病毒疗法
病毒载量
人口
解剖
环境卫生
作者
Aobo Dong,Lei Liu,Lin Xiao,Shu Liang,Kang Li,Jing Hu,Ran Kang,Jihong Xing,Chang Seon Song,Jun Yin,Shuiling Qu,Yuhua Ruan,Yi Feng,Lingjie Liao,Yiming Shao,Hui Xing
标识
DOI:10.1089/aid.2020.0034
摘要
In this study, we identified a novel circulating recombinant form (CRF) of HIV (CRF105_0108) in a total of five patients with no obvious epidemiological linkage in Sichuan, China. Four strains were found in this study, and another strain (XC2014EU01) was reported in a previous study. The phylogenetic analysis of the five near full-length genomes showed that a CRF08_BC segment was inserted into the CRF01_AE backbone with one recombinant breakpoint in the pol region, which is the first HIV-1 CRF of CRF01_AE and CRF08_BC. Three genetic sequences had drug-resistant mutations, E138Q and V179D, indicating that there were low resistance levels to efavirenz (EFV) and nevirapine (NVP) in Liangshan Yi Autonomous Prefecture. CRF105_0108 increases the diversity and complexity of the prevalent HIV-1 CRFs in Sichuan. Simultaneously, drug-resistant mutations in this CRF may influence the efficacy of highly active antiretroviral treatments (ARTs) in Liangshan Yi Autonomous Prefecture.
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