细胞周期蛋白依赖激酶
生物
核糖体生物发生
细胞生物学
细胞周期
激酶
癌症研究
背景(考古学)
细胞周期蛋白
癌症
遗传学
核糖体
核糖核酸
基因
古生物学
作者
Marina Bury,Benjamin Le Calvé,Gerardo Ferbeyre,Volker Blank,Frédéric Lessard
标识
DOI:10.1016/j.tcb.2021.01.010
摘要
Cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), control the transition between different phases of the cell cycle. CDK/cyclin activity is regulated by CDK inhibitors (CKIs), currently comprising the CDK-interacting protein/kinase inhibitory protein (CIP/KIP) family and the inhibitor of kinase (INK) family. Recent studies have identified a third group of CKIs, called ribosomal protein-inhibiting CDKs (RPICs). RPICs were discovered in the context of cellular senescence, a stable cell cycle arrest with tumor-suppressing abilities. RPICs accumulate in the nonribosomal fraction of senescent cells due to a decrease in rRNA biogenesis. Accordingly, RPICs are often downregulated in human cancers together with other ribosomal proteins, the tumor-suppressor functions of which are still under study. In this review, we discuss unique therapies that have been developed to target CDK activity in the context of cancer treatment or senescence-associated pathologies, providing novel tools for precision medicine.
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