Surface Science of Nanozymes and Defining a Nanozyme Unit

The field of nanozyme aims to use nanomaterials to replace protein-based enzymes. Nanozymes have attracted extensive interest because of their stability, cost-effectiveness, and versatility. While the focus of the nanozyme field has mainly been the discovery of new nanozyme materials and the exploration of their analytical, biomedical, and environmental applications, the number of fundamental studies is growing. Nanozymes are related to two important fields: enzymology and heterogeneous catalysis. Although fitting nanozyme kinetic data to the Michaelis–Menten kinetics is a very common practice, using the surface science methods of heterogeneous catalysis can provide insights about their catalytic mechanisms. The definition of a nanozyme unit is critical to understanding and comparing nanozyme activities. In this perspective, we articulate the use of a surface science approach to study nanozymes and discuss the various application scenarios of using different nanozyme units.