胶原酶
自愈水凝胶
材料科学
伤口愈合
纳米纤维
微生物胶原酶
人体皮肤
生物医学工程
聚己内酯
清创术(牙科)
纳米技术
化学
酶
医学
外科
生物化学
高分子化学
复合材料
聚合物
生物
遗传学
作者
Jerome Antunes,Artur Ribeiro,Daniela Lucas da Silva Lemos,Teresa Miranda,Jorge Gomes Santos,Graça M. B. Soares
出处
期刊:Materials Science Forum
日期:2022-06-10
卷期号:1063: 43-55
摘要
Collagenase acts by promoting wound debridement, contributing to the tissue repair process. Several studies pointed collagenase as a substance involved in the elimination of devitalized tissue or any contaminated material found in the wound bed after the appearance of a lesion or skin burn. In the present work hydroxypropyl methylcellulose/cyclodextrins hydrogels and polycaprolactone nanofibers with the ability to transport collagenase for the treatment of skin lesions, were synthesized and characterized. The collagenase polymeric carriers showed good physicochemical properties and presented the ability to retain the enzyme in its structure. Moreover, the PCL carriers did not display cytotoxic effect on human skin fibroblasts. Controlled release and in vitro diffusion studies revealed a slow release of active collagenase confirming the ability of the new systems to be used as carriers’ devices in the treatment of skin lesions.
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