Biosensor is a device that detects any change in physical parameter of biological elements in physicochemical manner and transfers its output in electrical manner. Nanotechnology is playing an emerging role in the development of biosensors and carbon nanotube is the leading one in this developing field. Carbon nanotube has an excellent combination of mechanical, electrical and electrochemical properties that has stimulated increasing interest in the application of CNTs as component in biosensors. This paper provides a review of analytical modeling of biosensors on the basis of carbon nanotube.