Fluorination methods for drug discovery and development

The development of new reagents for the safe and precise regioselective fluorination of biologically relevant compounds particularly in drug discovery remains a contemporary challenge in organic chemistry. However, significant strides have been made with the development of new deoxyfluorination reagents and the emergence of practical metal-mediated fluorination techniques have enabled the goal of efficient late-stage fluorination of drug-like compounds to be realized, and the extension of these methods for PET-labelling is being investigated.