Identification of poxvirus inside migrasomes suggests a novel mode of mpox virus spread

•Vaccinia virus is capable of inducing the formation of migrasomes. •Vaccinia virus proteins A4 and F13 are present in migrasomes. •Both IMV and IEV of vaccinia virus are detected inside migrasome. •Migrasome may play a role in the spread of poxviruses including mpox virus.