Age-Specific Risk of Second Primary Malignant Neoplasm After Radioactive Iodine Treatment for Differentiated Thyroid Cancer

This cohort study found that the risk of radioactive iodine-associated second primary malignant neoplasm among patients who received radioactive iodine for DTC varies significantly by age group, with distinct patterns in middle-aged compared with older adults. These findings suggest a need for age-specific surveillance strategies in radioactive iodine-treated DTC survivors. Further research is needed to establish optimal screening protocols.