A Standardized Psychological Intervention Procedure for Ovarian Cancer Patients Based on the Lazarus Stress Coping Model

Ovarian cancer patients often experience substantial psychological distress, which negatively affects treatment adherence and recovery; however, standardized psychological interventions remain limited in oncology care. To address this gap, this study develops and evaluates a standardized psychological intervention protocol based on the Lazarus stress coping model, aiming to reduce anxiety and depression and enhance coping capacity during chemotherapy. A randomized controlled pilot trial involving 70 participants was conducted, with patients randomly assigned to an intervention group (n = 35) receiving the protocol alongside chemotherapy or a control group (n = 35) receiving chemotherapy alone. The protocol integrates cognitive restructuring, emotional regulation training, coping skills education, and structured counseling into standard oncology care. Psychological distress and coping capacity were assessed using validated psychometric tools, including the Hospital Anxiety and Depression Scale (HADS), Self-Rating Depression Scale (SDS), and Self-Rating Anxiety Scale (SAS), and data were analyzed using independent-sample t-tests and chi-square tests. Results showed a significant reduction in combined anxiety-depression scores in the intervention group (from 11.77 ± 1.75 to 5.86 ± 1.78, p < 0.01), alongside improved emotional regulation and coping capacity. Positive but non-significant trends were also observed in embryological outcomes and clinical pregnancy rates (38.57%). These findings demonstrate that the proposed protocol is reproducible, theory-driven, and clinically feasible, offering potential to improve psychological well-being and treatment-related outcomes for ovarian cancer patients.