粒体自噬
衰老
线粒体
细胞生物学
糖酵解
氧化磷酸化
伤口愈合
胞外囊泡
新陈代谢
细胞代谢
生物
癌症研究
生物化学
细胞凋亡
自噬
免疫学
微泡
小RNA
基因
作者
Youyuan Zhuang,Shengjie Jiang,X. H. Deng,An Lao,Xiaolin Hua,Yun Xie,Lingyong Jiang,Xudong Wang,Kaili Lin
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-04-12
卷期号:10 (15)
标识
DOI:10.1126/sciadv.adl0372
摘要
Aging skin, vulnerable to age-related defects, is poor in wound repair. Metabolic regulation in accumulated senescent cells (SnCs) with aging is essential for tissue homeostasis, and adequate ATP is important in cell activation for aged tissue repair. Strategies for ATP metabolism intervention hold prospects for therapeutic advances. Here, we found energy metabolic changes in aging skin from patients and mice. Our data show that metformin engineered EV (Met-EV) can enhance aged mouse skin repair, as well as ameliorate cellular senescence and restore cell dysfunctions. Notably, ATP metabolism was remodeled as reduced glycolysis and enhanced OXPHOS after Met-EV treatment. We show Met-EV rescue senescence-induced mitochondria dysfunctions and mitophagy suppressions, indicating the role of Met-EV in remodeling mitochondrial functions via mitophagy for adequate ATP production in aged tissue repair. Our results reveal the mechanism for SnCs rejuvenation by EV and suggest the disturbed energy metabolism, essential in age-related defects, to be a potential therapeutic target for facilitating aged tissue repair.
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