细胞外基质
串扰
肿瘤微环境
免疫系统
医学
癌症治疗
癌症研究
癌症
免疫学
化学
内科学
生物
细胞生物学
物理
光学
作者
Lara Closset,Okan Gultekin,Sahar Salehi,Dhifaf Sarhan,Kaisa Lehti,Jordi Gonzalez‐Molina
标识
DOI:10.1016/j.matbio.2023.07.003
摘要
Targeting the tumour immune microenvironment (TIME) by cancer immunotherapy has led to improved patient outcomes. However, response to these treatments is heterogeneous and cancer-type dependant. The therapeutic activity of classical cancer therapies such as chemotherapy, radiotherapy, and surgical oncology is modulated by alterations of the TIME. A major regulator of immune cell function and resistance to both immune and classical therapies is the extracellular matrix (ECM). Concurrently, cancer therapies reshape the TIME as well as the ECM, causing both pro- and anti-tumour responses. Accordingly, the TIME-ECM crosstalk presents attractive opportunities to improve therapy outcomes. Here, we review the molecular crosstalk between the TIME and the ECM in cancer and its implications in cancer progression and clinical intervention. Additionally, we discuss examples and future directions of ECM and TIME co-targeting in combination with oncological therapies including surgery, chemotherapy, and radiotherapy.
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