The Effect of Glucagon-Like Peptide 1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion

胰高血糖素 内科学 内分泌学 秘书 胰岛素 胰高血糖素样肽-1 胰高血糖素样肽1受体 刺激 生理盐水 内生 胰高血糖素受体 丸(消化) 化学 受体 生物 糖尿病 医学 2型糖尿病 兴奋剂
作者
RAHELE A. FARAHANI,Aoife M Egan,Andrew Welch,Marcello C. Laurenti,Claudio Cobelli,Chiara Dalla Man,Adrian Vella
出处
期刊:Diabetes [American Diabetes Association]
卷期号:72 (4): 449-454
标识
DOI:10.2337/db22-0709
摘要

Data from transgenic rodent models suggest that glucagon acts as an insulin secretagogue by signaling through the glucagon-like peptide 1 receptor (GLP-1R) present on β-cells. However, its net contribution to physiologic insulin secretion in humans is unknown. To address this question, we studied individuals without diabetes in two separate experiments. Each subject was studied on two occasions in random order. In the first experiment, during a hyperglycemic clamp, glucagon was infused at 0.4 ng/kg/min, increasing by 0.2 ng/kg/min every hour for 5 h. On one day, exendin-9,39 (300 pmol/kg/min) was infused to block GLP-1R, while on the other, saline was infused. The insulin secretion rate (ISR) was calculated by nonparametric deconvolution from plasma concentrations of C-peptide. Endogenous glucose production and glucose disappearance were measured using the tracer-dilution technique. Glucagon concentrations, by design, did not differ between study days. Integrated ISR was lower during exendin-9,39 infusion (213 ± 26 vs. 191 ± 22 nmol/5 h, saline vs. exendin-9,39, respectively; P = 0.02). In the separate experiment, exendin-9,39 infusion, compared with saline infusion, also decreased the β-cell secretory response to a 1-mg glucagon bolus. These data show that, in humans without diabetes, glucagon partially stimulates the β-cell through GLP-1R.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
cczz发布了新的文献求助10
1秒前
我是老大应助科研通管家采纳,获得10
1秒前
qwq发布了新的文献求助10
1秒前
1秒前
酷波er应助科研通管家采纳,获得10
1秒前
华仔应助志灰灰采纳,获得10
1秒前
二三十发布了新的文献求助30
2秒前
青炀应助科研通管家采纳,获得10
2秒前
寂寞的故事完成签到,获得积分10
2秒前
大个应助科研通管家采纳,获得10
2秒前
bkagyin应助科研通管家采纳,获得30
2秒前
无极微光应助科研通管家采纳,获得20
2秒前
2秒前
2秒前
CodeCraft应助科研通管家采纳,获得10
2秒前
顾矜应助科研通管家采纳,获得10
2秒前
kangkang完成签到,获得积分10
2秒前
2秒前
顾矜应助科研通管家采纳,获得10
2秒前
2秒前
Akim应助科研通管家采纳,获得10
2秒前
大模型应助科研通管家采纳,获得10
2秒前
2秒前
大模型应助科研通管家采纳,获得10
2秒前
大个应助科研通管家采纳,获得10
3秒前
3秒前
3秒前
3秒前
番茄的蛋发布了新的文献求助10
3秒前
天栽奇才小高完成签到,获得积分10
4秒前
Ting完成签到,获得积分10
4秒前
天天快乐应助nature预备军采纳,获得10
4秒前
4秒前
4秒前
FashionBoy应助愉快啊啊采纳,获得10
5秒前
乂领域发布了新的文献求助20
5秒前
5秒前
5秒前
5秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Picture this! Including first nations fiction picture books in school library collections 2000
The Cambridge History of China: Volume 4, Sui and T'ang China, 589–906 AD, Part Two 1500
Cowries - A Guide to the Gastropod Family Cypraeidae 1200
ON THE THEORY OF BIRATIONAL BLOWING-UP 666
Signals, Systems, and Signal Processing 610
Pulse width control of a 3-phase inverter with non sinusoidal phase voltages 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 物理 内科学 复合材料 催化作用 物理化学 光电子学 电极 细胞生物学 基因 无机化学
热门帖子
关注 科研通微信公众号,转发送积分 6390319
求助须知:如何正确求助?哪些是违规求助? 8205444
关于积分的说明 17366054
捐赠科研通 5444033
什么是DOI,文献DOI怎么找? 2878484
邀请新用户注册赠送积分活动 1854930
关于科研通互助平台的介绍 1698169