动力学
化学
一氧化碳
磺胺
生物正交化学
荧光
组合化学
前药
化学动力学
生物物理学
催化作用
点击化学
立体化学
有机化学
生物化学
生物
量子力学
物理
作者
Miao Liu,Yuhan Wang,Zhicheng Yan,Jiabin Yang,Yongyou Wu,Dawei Ding,Xingyue Ji
出处
期刊:ChemBioChem
[Wiley]
日期:2022-12-23
卷期号:24 (3)
被引量:2
标识
DOI:10.1002/cbic.202200506
摘要
Abstract Bioorthogonal prodrugs with both fast reaction kinetics and multiple outputs are highly desirable but are only found sporadically. Herein, we report a novel photoclick‐and‐release strategy for the co‐activation of carbon monoxide and a self‐reporter, carbonyl sulfide, or sulfonamide with fast reaction kinetics ( k : 1.4–22.6 M −1 s −1 ). Such a photoclick‐and‐release strategy was successfully applied in live cells to deliver carbon monoxide and a fluorescent self‐reporter, both of which exhibited pronounced antiproliferative activity against 4T1 cancer cells. It is conceivable that this photoclick‐and‐release strategy could find applications in other fields, in which a controlled bond cleavage is preferred.
科研通智能强力驱动
Strongly Powered by AbleSci AI