菱形
结肠炎
生物
溃疡性结肠炎
微生物群
潘尼斯电池
免疫学
信号转导
癌症研究
医学
细胞生物学
生物信息学
内科学
生物化学
罗亚
小肠
疾病
作者
Jianming Yang,Geng Pei,Xuan Sun,Yuxiu Xiao,Chunhui Miao,Lu Zhou,Bangmao Wang,Yang Liu,Mingyu Yu,Zhisong Zhang,Evan T. Keller,Zhi Yao,Quan Wang
出处
期刊:Microbiome
[Springer Nature]
日期:2022-09-16
卷期号:10 (1)
被引量:13
标识
DOI:10.1186/s40168-022-01347-3
摘要
The pathogenesis of inflammatory bowel diseases (IBD) is multifactorial, and diagnostic and treatment strategies for IBD remain to be developed. RhoB regulates multiple cell functions; however, its role in colitis is unexplored.Here, we found RhoB was dramatically increased in colon tissues of ulcerative colitis (UC) patients and mice with DSS-induced colitis. Compared with wild type mice, RhoB+/- and RhoB-/- mice developed milder DSS-induced colitis and increased goblet cell numbers and IEC proliferation. Decreased RhoB promoted goblet cell differentiation and epithelial regeneration through inhibiting Wnt signaling pathway and activating p38 MAPK signaling pathway. Moreover, increased SCFA-producing bacteria and SCFA concentrations were detected in intestinal microbiome of both RhoB+/- and RhoB-/- mice and upregulated SCFA receptor expression was also observed.Taken together, a higher level of RhoB is associated with UC, which also contributes to UC development through modulating cell signaling and altering intestinal bacterial composition and metabolites. These observations suggest that RhoB has potential as a biomarker and a treatment target for UC. Video Abstract.
科研通智能强力驱动
Strongly Powered by AbleSci AI