主动脉
医学
儿茶酚胺
内科学
冠状动脉粥样硬化
动脉
胆固醇
心脏病学
内分泌学
体重
冠状动脉
冠状动脉疾病
作者
R. S. Kukreja,B N Datta,R. N. Chakravarti
出处
期刊:Atherosclerosis
[Elsevier]
日期:1981-11-01
卷期号:40 (3-4): 291-298
被引量:58
标识
DOI:10.1016/0021-9150(81)90139-8
摘要
Advanced aortic and coronary atherosclerosis was produced in rhesus monkeys by means of two procedures' (a) high fat and cholesterol feeding for 7 months, and (b) this diet coupled with daily i.v. injection of adrenaline (50 micrograms/kg body weight). A total of 83% of the monkeys subjected to procedure (b) developed markedly advanced atherosclerosis in the form of fibrous plaques in the aorta and coronary artery, while these lesions were much less frequent in the other group. The ratio of total to free serum cholesterol, significantly increased and the aortic cholesterol content was very high in monkeys subjected to both the atherogenic diet and adrenaline injections. It is suggested that catecholamines cause vascular injury and, in the presence of hyperlipidaemia, cause accelerated and aggravated atherosclerosis.
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