Effect of total ginsenoside on memory impairment induced by β amyloid peptide

AIM To observe the effect of total ginsenoside on learning and memory impairment induced by β amyloid peptide(β AP). METHODS Aggregated β AP(25～35) 3 μl (1 0 mmol·L -1 ) icv once to mice was used as an AD animal model. In step through test and Morris water maze test, the effects of total ginsenoside ig once a day at doses of 100,50,25 mg·kg -1 on β AP(25～35) induced memory impairment were observed. RESULTS In mice, aggregated β AP(25～35) induced obvious learning and memory impairment in step through test 8 days and in Morris water maze test 11 days after icv β AP(25～35). Total ginsenoside 100,50,25 mg·kg -1 significantly improved memory impairment induced by β AP(25～35). CONCLUSION The β AP(25～35) icv can impaire memory. Total ginsenoside improves memory impairment induced by aggregated β AP(25～35).