Objective: To present a method for mandibular defects reconstruction with free fibular flap by CAD/CAM.Methods: Plan was conducted by using the Mimics software simulating surgery on a personal computer.The osteotomies were translated into rapid prototyping guides,sterilized and applied during surgery on the fibula allowing for the osteotomies and osteosynthesis to be performed with intact circulation.Results: During operation,the fibula flap could be cut in appropriate length.Cutting,reformation and reposition of the fibula could be accelerated by surgery guides.Conclusion: Application of CAD/CAM has good results in mandibular defects reconstruction with free fibular flap.