Telomere binding protein TRF2

TRF2 (TTAGGG repeat binding factor-2) is a telomere-related protein. Dimerized TRF2 proteins bind to the telomere repeat squence TTAGGG via their Myb motif. TRF2, TRF1, Rap1, TTN2, TINT1 as well as POT1 assemble a protein complex called shelterin and cooperate to play key roles in maintaining the homeostasis of telomeres. TRF2 not only functions on modeling telomere morphology, controlling telomere length and protecting 3' G-rich overhang, but also regulates the stability of genome. Beyond telomere, TRF2 could be involved in DNA damage response system when telomeric or non-telomeric DNA damage occurrs in cells.