Synthesis and Secretion of Hepatic Very Low-Density Lipoprotein:a Review

Excess deposition of very low-density lipoproteins(VLDL) leading to lipid metabolic disorders is the major cause of fatty liver.This review provides the latest understanding in aspects of VLDL assembly process and factors affecting hepatic VLDL synthesis and secretion,including structure-function relationships within apolipoprotein B-100(apoB-100),role of microsomal triglyceride transfer protein(MTP) in modulating VLDL synthesis,and other hepatic proteins and fatty acids contributing to VLDL assembly.In addition,some suggestions on studying molecular and cellular mechanisms of VLDL synthesis and secretion are proposed,and the perspectives of VLDL applications in animal husbandry are also discussed.