Bone metabolism is the course of dynamic balance between bone formation and bone resorption, and can produce some metabolites. These metabolites are named for markers of bone turnover, and classified into markers of bone formation and markers of bone resorption. Markers of bone formation represent the activity of osteoplast and metabolite of bone formation, and markers of bone resorption represent the activity of osteoclast and metabolite of bone resorption. In this review, the researches on neonatal markers of bone turnover were discussed.