The Effect and Mechanism of Bisphenol A on the Reproductive System

Bisphenol A(Bisphenol A,BPA) is one of the phenolic environmental estrogens,exposured to doses of BPA would have certain impact on the organism,including the reproductive system,embryonic development,central nervous system,the occurrence of tumors etc.Especially on the reproductive system,BPA may act on the male mammal,such as gonadal dysgenesis,decrease in the number of sperm etc.At the same time,BPA may act on the female mammals,changed the morphology and function of vagina,uterus,ovary etc.The effect of BPA on the reproductive system through several pathways,BPA may play a role through the following ways:estrogen nuclear receptor and membrane receptor、estrogen-related receptor、the hypothalamus-pituitary-gonadal axis.This paper reviewed bisphenol A on the reproductive system and its possible mechanism.