Measurement of Serum NT-proBNP Level in Patients with Acute Myocardial Infarction and Its Clinical Significance

Objective To investigate the relationship among serum NT-proBNP level,myocardial infarct size,cardiac function and inhospital main adverse cardiac events(MACE) in patients with acute myocardiac infarction(AMI).Method The serum concentration of NT-proBNP in 41 patients with AMI and 39 healthy subjects were measured within 48h after admission by ELISA methods.The results were contrasted and analyzed with the peak concentrations of serum creatine kinase(CK) and its isoenzyme CK-MB,left ventricular ejection fraction(LVEF) as well as inhospital MACE.Results Serum NT-proBNP concentration in patients with AMI was significantly higher than that in healthy subjects(699.44±386.28pg/ml vs 41.75±24.26pg/ml,P0.001).There was a positive correlation between serum NT-proBNP concentration and peak concentrations of CK(r=0.817,P=0.001) and CK-MB(r=0.772,P=0.001) in patients with AMI.There was a negative correlation between serum NTproBNP concentration and LVEF(r=-0.661,P0.01).The serum NT-proBNP concentration in patients with inhospital MACE was significantly higher than that in patients without MACE(971.50±367.01pg/ml vs 393.60±261.16pg/ml,P0.001).Conclusions Serum NT-proBNP concentration in patients with AMI is positively correlated with peak concentrations of CK and CK-MB,and is negatively correlated with LVEF.The measurement of serum NT-proBNP concentration might predict the myocardial infarct size,cardiac function and inhospital MACE rate in patients with AMI.