The effect of Nivalenol on the metabolism of Hyaluronic Acid

Objective:The purpose of the study is to discover the effect of nivalenol and selenium on the metabolism of hyaluronic acid, in order to explore the role of the suspected etiological factor in the process of Kashin-Beck Disease. Method Hyaluronan synthase-2 mRNA expression was measured by RT-PCR and radioimmunoprecipitation method was used to detect the levels of hyaluronic acid in culture medium. Result NIV increased hyaluronan synthase-2 mRNA expression. After Se was added, the mRNA levels did not change significantly compared with the groups without Se. The content of hyaluronic acid in medium with NIV was higher than that in other groups. Conclusion NIV has a significant effect on chondrocytes cultured in vitro, it can perturb hyaluronic acid synthsis and metabolism, which eventually lead to the metabolic disorder of the cartilage matrix components. Supplying Se can partially alleviate the damage of NIV on cartilage.