Cisplatin nephrotoxicity in male beagle dogs: next-generation protein kidney safety biomarker tissue expression and related changes in urine

In dogs, CDDP induced corticomedullary tubular lesions [A.]; clusterin (CLU) staining in damaged medullary tubules [B.]; and elevated urinary CLU [C.]. Baseline CLU was detected from Control dogs [A. and C.].