二硒醚
胶束
药物输送
聚乙二醇
药品
PEG比率
毒品携带者
生物物理学
材料科学
化学
组合化学
药理学
纳米技术
生物化学
有机化学
医学
生物
经济
水溶液
硒
财务
作者
V. G. Deepagan,Seunglee Kwon,Dong Gil You,Van Quy Nguyen,Wooram Um,Hyewon Ko,Hansang Lee,Dong Gyu Jo,Young Mo Kang,Jae Hyung Park
出处
期刊:Biomaterials
[Elsevier]
日期:2016-10-01
卷期号:103: 56-66
被引量:146
标识
DOI:10.1016/j.biomaterials.2016.06.044
摘要
Stimuli-responsive micelles have emerged as the drug carrier for cancer therapy since they can exclusively release the drug via their structural changes in response to the specific stimuli of the target site. Herein, we developed the in situ diselenide-crosslinked micelles (DCMs), which are responsive to the abnormal ROS levels of tumoral region, as anticancer drug carriers. The DCMs were spontaneously derived from selenol-bearing triblock copolymers consisting of polyethylene glycol (PEG) and polypeptide derivatives. During micelle formation, doxorubicine (DOX) was effectively encapsulated in the hydrophobic core, and diselenide crosslinks were formed in the shell. The DCMs maintained their structural integrity, at least for 6 days in physiological conditions, even in the presence of destabilizing agents. However, ROS-rich conditions triggered rapid release of DOX from the DOX-encapsulating DCMs (DOX-DCMs) because the hydrophobic diselenide bond was cleaved into hydrophilic selenic acid derivatives. Interestingly, after their systemic administration into the tumor-bearing mice, DOX-DCMs delivered significantly more drug to tumors (1.69-fold and 3.73-fold higher amount compared with their non-crosslinked counterparts and free drug, respectively) and effectively suppressed tumor growth. Overall, our data indicate that DCMs have great potential as drug carriers for anticancer therapy.
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