The microscopic study of thrombus in vitro thrombolytic test in acute cerebral infarction

Objective:To study the impress of urokinase(UK) in thrombolytic therapy of acute cerebral infarction by observing the extrabody thrombus model's density variation under optic and election microscopes and to provide the theories for the clinical individual thrombolytic therapy.Methods:30 patients with acute cerebral infarction within 12h were treated with UK at the dose detemined by vitro thrombolytic test and then were given UK 40MU each day in the later 7 days.Extrabody thrombus models length and wet weight were measured.The pathological changes of extrabody thrombus models were observed and the length of fibronectin was measured.Face density was analysed by picture analysis system.Neural function damaged situation was admitted at the thrombolytic at once,1d,3d,7d.Results:In different density urokinase fibronectin's length and face density were different..The organization structure of extrabody thrombus models showed:it was filled with the great quantities of red cells,platelet and fibrinogen,they constituted the feber net structure under optic.Conclusion:The pathology structure of thrombus in models has the same structure as body thrombus.Vitro thrombolytic test guiding to thrombolytic therapy is viable.