视网膜
细胞生物学
钙黄绿素
胶质纤维酸性蛋白
睫状神经营养因子
生物
人口
程序性细胞死亡
诺金
神经营养因子
高氧
化学
分子生物学
骨形态发生蛋白
免疫学
受体
神经科学
医学
免疫组织化学
生物化学
有机化学
细胞凋亡
氧气
环境卫生
基因
作者
Arturo Bravo‐Nuevo,Alice Brandli,Jacquelyn Gerhart,Jennifer Nichols,Meghan Pitts,Christopher K. Sutera,Sarah Assali,Victoria Scheinfeld,George C. Prendergast,Jonathan Stone,Mindy George‐Weinstein
标识
DOI:10.1016/j.exer.2015.11.023
摘要
Myo/Nog cells are essential for eye development in the chick embryo and respond to injury in adult tissues. These cells express mRNA for the skeletal muscle specific transcription factor MyoD, the bone morphogenetic protein (BMP) inhibitor Noggin and the cell surface protein recognized by the G8 monoclonal antibody (mAb). In this study, we determined that Myo/Nog cells are present in low numbers in the retina of the mouse eye. G8-positive Myo/Nog cells were distinguished from neuronal, Müller and microglial cells that were identified with antibodies to calretinin, Chx10, glial fibrillary acidic protein and ionized calcium binding adaptor molecule 1, respectively. In the neonatal retina, the number of Myo/Nog cells increased in parallel with cell death induced by transient exposure to hyperoxia. In this model of retinopathy of prematurity, depletion of Myo/Nog cells by intravitreal injection of the G8 mAb and complement increased cell death. These findings demonstrate that Myo/Nog cells are a distinct population of cells, not previously described in the retina, which increases in response to retinal damage and mitigate hypoxia-induced cell death.
科研通智能强力驱动
Strongly Powered by AbleSci AI