Celecoxib Nanoemulsion for Transdermal Drug Delivery: Characterization and In Vitro Evaluation

Abstract The's aim of the present study was to investigate the potential of nanoemulsions for transdermal delivery of celecoxib. The prepared nanoemulsions were subjected to different dispersion stability tests and characterized for morphology, viscosity, droplet size, and refractive index. The in vitro skin permeation profile of optimized formulation was compared with celecoxib gel and nanoemulsion gel. Significant increase in permeability parameters was observed in nanoemulsion formulations (p < 0.05). These results suggest that nanoemulsions are potential vehicles for improved transdermal delivery of celecoxib. Keywords: Celecoxibnanoemulsion gelsnanoemulsionsphase diagramstransdermal delivery The authors are grateful to University Grant Commission (UGC), New Delhi, India for providing financial support for this project. The authors are also thankful to Gattefosse, France for providing the gift samples of oils, surfactants and cosurfactants. Notes a Mean ± SD, n = 3. ∗Oil phase containing 2% w/w of CXB in all formulations. CXB = Celecoxib, IPA = Isopropyl alcohol, PEG-400 = Polyethylene glycol-400, PG = Propylene glycol, TEA = Triethanolamine. a For 100 g of gel, q.s. = quantity sufficient. a Mean ± SD, n = 3. ∗Celecoxib (CXB) gel was used as control formulation. a Mean ± SD, n = 3. Part of the special issue, Surface and Colloid Chemistry Without Borders: An International Festschrift for Professor Per Stenius on the Occasion of His 70th Birthday.