CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response

TRIM28 functions as a negative regulator of RIG-I-mediated antiviral signaling by promoting K48-linked ubiquitination of MAVS. These findings define the TRIM28-MAVS axis as a regulatory checkpoint in innate antiviral immunity and suggest its potential as a target for antiviral intervention.