Treatment of supratrochlear and supraorbital veins with long-pulsed 1064-nm Nd: YAG laser: A single-arm prospective pilot study

Background Supratrochlear and supraorbital veins are a frequent cosmetic concern in aesthetic dermatology, with limited efficacy/safety prospective data on noninvasive treatments. The long-pulsed 1064-nm Nd:YAG laser offers deeper tissue penetration and low melanin absorption, potentially enabling safe and effective management of these vessels. Methods This prospective, single-center pilot study included 10 adult patients with visible supratrochlear and supraorbital veins deemed aesthetically undesirable. All participants underwent two sessions of long-pulsed 1064-nm Nd:YAG laser treatment (6-mm spot, 70–90 J/cm 2 , 40 ms) at 30-days intervals, with dynamic skin cooling. The primary efficacy outcome was the quantitative ultrasonographic analysis of venous caliber reduction. Co-primary outcomes included blinded evaluator photographic assessments and safety evaluation. Secondary outcomes comprised patient-reported outcomes via a satisfaction questionnaire. Results Ultrasonographic measurements demonstrated a significant reduction in venous caliber after treatment (0.17 ± 0.05 cm vs 0.12 ± 0.05 cm; p < 0.001). No significant differences were detected by blinded evaluators between pre- and post-treatment photographs (κ = 0.176). No skin alterations occurred at any time point. Nine patients (90%) rated the results as “very good” or “excellent,” with none rating them as “poor” or “very poor”. Conclusion Long-pulsed 1064-nm Nd:YAG laser treatment of supratrochlear and supraorbital veins led to a significant ultrasonographic reduction in venous caliber and high patient satisfaction without adverse cutaneous effects.