Heterogeneous Fe single-atom catalysis for C2–H amidation of pyridine/quinoline N-oxides: streamlined synthesis of pharmaceutical scaffolds

We present a novel single-atom catalytic strategy for direct C2-H amidation of pyridine/quinoline N-oxides, employing a nitrogen-doped carbon matrix to stabilize atomic iron sites (Fe-N/C). This heterogeneous system overcomes critical...