H-silicene nanosheets as a novel therapeutic approach for disuse muscle atrophy by modulating macrophage polarization

This study demonstrates that H-silicene alleviates disuse-induced muscle atrophy by promoting the transition from pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophages and remodeling the local immune microenvironment, making it a promising nanotherapeutic for muscle-wasting disorders.