Screen-Printed Electrode (SPE)-Based Biosensor for Point-Of-Care (POC) Diagnostic in Medical Applications, Their Scope, and Challenges

The present chapter focuses mainly on advancing screen-printed electrode (SPE) technology to target toxic biomolecules with point-of-care (POC) diagnostic in biomedical applications. Various SPE parameters, such as general fabrication process steps, suitable material, the dynamic range of detection, and the limit of detection (LOD) for biosensor application, have been discussed here. Furthermore, the SPE is a low-cost approach compared with other technology in terms of simplicity, time of detection, and inexpensive fabrication, but still need to have post-processing of detected signal in real time for POC diagnostic biosensor applications, and it remains a significant challenge. Notably, the disposability factor is another desirable biosensor parameter that must be considered at the global environmental level. Paper and flexible substrate-based sensors are emerging research areas that reduce the overall production cost and improve the fabricated biosensor’s sensitivity. Here, we also provide SPE application to detect the top five deadliest diseases worldwide, such as cardiovascular disease (CVD), respiratory cancers (RS), diabetes mellitus (DM), Alzheimer’s disease (AD), and tuberculosis (TB) according to death rates per year. This chapter also focuses on the advancement and future scope of SPE technology in POC diagnostic for biosensor applications.