癌症研究
癌症干细胞
癌变
胰腺癌
组蛋白H3
EZH2型
表观遗传学
生物
干细胞
转录因子
癌症
细胞生物学
遗传学
基因
作者
Yuliang Feng,Liuyang Cai,Martin Pook,Feng Liu,Chao‐Hui Chang,Mai Abdel Mouti,Reshma Nibhani,Stefania Militi,James Dunford,Martin Philpott,Yanbo Fan,Guo‐Chang Fan,Qi Liu,Jun Qi,Cheng Wang,Wanzi Hong,Hannah Morgan,Mingyang Wang,Sakthivel Sadayappan,Anil G. Jegga
标识
DOI：10.1053/j.gastro.2023.09.021
摘要
The dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) is linked to the presence of pancreatic cancer stem-like cells (CSCs) that respond poorly to current chemotherapy regimens. The epigenetic mechanisms regulating CSCs are currently insufficiently understood, which hampers the development of novel strategies for eliminating CSCs.
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