Untapping the Potential of Astragaloside IV in the Battle Against Respiratory Diseases

Respiratory diseases are an emerging public health concern, that pose a risk to the global community.There, it is essential to establish effective treatments to reduce the global burden of respiratory diseases.Astragaloside IV (AS-IV) is a natural saponin isolated from Radix astragali (Huangqi in Chinese) used for thousands of years in Chinese medicine.This compound has become increasingly popular due to its potential anti-inflammatory, antioxidant, and anticancer properties.In the last decade, accumulated evidence has indicated the AS-IV protective effect against respiratory diseases.This article presents a current understanding of AS-IV roles and mechanisms in combatting respiratory diseases.The ability of the agent to suppress oxidative stress, cell proliferation, and epithelial-mesenchymal transition (EMT), to attenuate inflammatory responses, and modulate programmed cell death (PCD) will be discussed.This review highlights the current challenges in respiratory diseases and recommendations to improve disease management.