[Predictive Value of Complete Blood Count and Inflammation Marker on Risk of Recurrence in Children with Henoch-Schönlein Purpura].

To investigate the predictive value of complete blood count (CBC) and inflammation marker on the recurrence risk in children with Henoch-Schönlein purpura (HSP).One hundred and thirty-three children with HSP admitted to Cangzhou Central Hospital from February 2017 to March 2019 were enrolled. The clinical data of the children were collected, at the time of admission CBC and C-reactive protein (CRP) were detected. After discharge, the children were followed up for 1 year, the clinical data of children with and without recurrence were compared, and multivariate logistic regression was used to analyze the risk factors affecting HSP recurrence. Receiver operating characteristic (ROC) curve should be drawn and the predictive value of CBC and CRP on HSP recurrence should be analyzed.In the follow-up of 133 children, 8 cases were lost and 39 cases recurred, with a recurrence rate of 31.20% (39/125). The age, skin rash duration, proportion of renal damage at the initial onset, percentage of neutrophils, percentage of lymphocytes, platelet count (PLT), mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), MPV/PLT ratio (MPR), and CRP level of patients with recurrence were statistically different from those without recurrence (P <0.05). Multivariate logistic regression analysis showed that long skin rash duration, renal damage at the initial onset, increased PLR, high PLT, increased MPV and elevated CRP level were independent risk factors for recurrence in children with HSP (P <0.05). The ROC curve analysis showed that the area under the curve (AUC) of the combination of the four blood and inflammation marker (PLT, MPV, PLR and CPR) in the early prediction of HSP recurrence was 0.898, which was higher than the initial renal damage (AUC=0.687) and persistent skin rash time (AUC=0.708), with a sensitivity of 84.62% and a specificity of 83.72%.Observation of CBC and CPR can predict the risk of HSP recurrence early and guide early clinical intervention.血液及炎症指标对过敏性紫癜患儿复发风险的预测价值.探讨血常规及炎症指标对过敏性紫癜（HSP）患儿复发风险的影响。.纳入2017年2月至2019年3月沧州市中心医院收治的HSP患儿133例，收集患儿入院时的临床资料，于入院当天检测患儿血常规、C反应蛋白等指标，出院后随访1年，比较复发和未复发患者的临床资料，对影响复发的因素进行多因素Logistic回归分析。绘制受试者工作特征曲线，分析血常规和炎症指标对早期预测HSP复发的价值。.133例患儿随访过程中8例失访，最终有39例复发，复发率为31.20%（39/125）。复发患者的年龄、皮疹持续时间、初发时肾损害比例、中性粒细胞百分比、淋巴细胞百分比、血小板数、平均血小板体积以及中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、平均血小板体积/血小板计数比值、C反应蛋白水平与未复发患者比较存在统计学差异（P <0.05）。多因素Logistic回归分析结果显示，皮疹持续时间长、初发时肾损害、血小板/淋巴细胞比值增大、血小板数高、平均血小板体积值大以及C反应蛋白水平高是HSP患儿复发的独立危险因素（P <0.05）。ROC曲线分析结果显示，4项血液及炎症指标（血小板、平均血小板体积、血小板/淋巴细胞比值和C反应蛋白）联合在早期预测HSP复发的曲线下面积（AUC）为0.898，高于初发时肾损害（AUC=0.687）和皮疹持续时间（AUC=0.708），其敏感度为84.62%，特异度为83.72%。.通过观察血常规和C反应蛋白能够对HSP复发风险做到早期预测，指导临床早干预。.