Involvement of the astroglial glutamate–glutamine cycle in the analgesic effects of electroacupuncture in a rat model of chronic neuropathic pain

Repeated EA administration inhibited CCI-induced chronic neuropathic pain in rats, corresponding to a reversal of decreased expression of GLAST and GLT-1, which may have accelerated the clearance of Glu and thereby reduced its concentration. Regulation of the astroglial glutamate-glutamine cycle is a potential target of EA.