再生(生物学)
医学
肝再生
干细胞
肝衰竭
小RNA
生物信息学
病理
细胞生物学
内科学
生物
遗传学
基因
作者
Madelyn J. Blake,Clifford J. Steer
标识
DOI:10.1016/j.cld.2023.03.005
摘要
Liver regeneration is a multifaceted process by which the organ regains its original size and histologic organization. In recent decades, substantial advances have been made in our understanding of the mechanisms underlying regeneration following loss of hepatic mass. Liver regeneration in acute liver failure possesses several classic pathways, while also exhibiting unique differences in key processes such as the roles of differentiated cells and stem cell analogs. Here we summarize these unique differences and new molecular mechanisms involving the gut-liver axis, immunomodulation, and microRNAs with an emphasis on applications to the patient population through stem cell therapies and prognostication.
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