医学
肺动脉高压
心脏病学
内科学
算法
计算机科学
作者
Kelly Chin,Seán Gaine,Christian Gerges,Zhi‐Cheng Jing,Stephen C. Mathai,Yuichi Tamura,Vallerie V. McLaughlin,Olivier Sitbon
出处
期刊:The European respiratory journal
[European Respiratory Society]
日期:2024-08-29
卷期号:64 (4): 2401325-2401325
被引量:207
标识
DOI:10.1183/13993003.01325-2024
摘要
Pulmonary arterial hypertension leads to significant impairment in haemodynamics, right heart function, exercise capacity, quality of life and survival. Current therapies have mechanisms of action involving signalling via one of four pathways: endothelin-1, nitric oxide, prostacyclin and bone morphogenetic protein/activin signalling. Efficacy has generally been greater with therapeutic combinations and with parenteral therapy compared with monotherapy or nonparenteral therapies, and maximal medical therapy is now four-drug therapy. Lung transplantation remains an option for selected patients with an inadequate response to therapies.
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