化学
庞加米亚
色酮
衍生工具(金融)
传统医学
立体化学
全合成
有机化学
催化作用
医学
生物柴油
金融经济学
经济
作者
Hongbo Dong,Ying Li,Pei Yu,Hefei Shi,Ting-Ting Yang,Chuanling Feng,Yujiao He
出处
期刊:Letters in Organic Chemistry
[Bentham Science]
日期:2023-06-01
卷期号:20 (6): 562-567
标识
DOI:10.2174/1570178620666221230145816
摘要
Abstract: Karanjin (1) is a natural furanoflavonol derivative isolated from seeds of Pongamia pinnata (L.) Pierre. In this paper, we have accomplished a concise total synthesis of karanjin (1) as well as its natural analogues pongapinnol D (2), 3-hydroxy-6-methoxy-2-phenyl-4H-furo[2,3-h]-1-benzopyran- 4-one (3) and 3,6-dimethoxy-2-phenyl-4H-furo[2,3-h]chromen-4-one (4). One-pot aerobic oxidation was the key step to afford the flavonol framework under mild conditions. The anti-inflammatory properties of synthesized 1–4 were determined against NO production in the LPS-stimulated RAW264.7 cells.
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